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10.1016/0006-8993(91)90730-j 97 KimJ

Moreover, the therapy-induced immune response may limit the efficacy by neutralizing antibodies with drugs or restrict the security through inducing inflammatory responses (215)

doi: 10.1002/jbm4.10209 61 MaXMengJJiaMBiLZhouYWangYet al

Epithelial binding of 1,2-dibromoethane (EDB) in the respiratory and upper alimentary tracts of mice and rats

Such non-specific interactions reduce the concentration of free drug, diminish effective accumulation in target tissues, and can accelerate metabolic clearance [65, 72,73,74]